Cosmetics pollutants and hazardous

The collapse of a myth: The Cosmetics beautifies or CONTAMINATES?



According to a study conducted by the University of Reading (UK) and published in January 2004 in the Journal of Applied Toxicology (Darbre PD et al.), Some chemical substances in deodorants, such as "Parabens" could encourage onset of breast cancers.
The parabens are esters of para-hydroxy benzoic acid and are used for storage of cosmetic products (Elder et al., 1984).
(Editor's note: Parabens (ethyl esters, methyl and propyl paraidrossibenzoico) are bactericidal and fungicidal substances, used for their antioxidant and anti-fermentative, are found in many cosmetics, skin creams and adhesive bandages, detergents for home, in the shoe polish and finally in shampoos and soaps.
The greater the contact with the skin, the greater the risk of sensitization.
Are present as preservatives in foods in the long term, seasonings, tomato concentrates, dairy products, jams, jellies, preserved fish, sausages, even in soft drinks such as lemonade, fruit juices.
They are also found in topical medications, such as eye drops, ear drops and nose, in toothpastes).
They represent, in particular, the more substances present in products for the hygiene of the body as they are considered among the most effective antimicrobial agents, an activity that increases with the length of their chain ester (Murrel et al., 1950). Their wide use, also, is due to the fact that they are considered, for years now innocuous compounds, are well tolerated by the skin and especially active at low concentrations (<1%) (Elder et al. 1984).
The alarm on their potential hazard has been prevalent since the results of the study conducted by the University of Reading have shown that of the 20 samples taken from women with breast cancer and examined, fewer than 18 had high traces of parabens in particular metilparabeni.
In addition, in four of the twenty samples the total concentration of parabens was about two times higher than the average values ​​found in twenty patients. Their power is derived carcinogen, as stated by this study, the ability of parabens act like estrogen (Routledge et al., 1998 Byford et al., 2002; Darbre et al., 2002, 2003), hormones that women naturally produce from puberty to menopause and that taken in large quantities, could facilitate the proliferation of cancer cells. In particular parabens over that bind to estrogen receptors are also able to regulate the expression of genes (eg. pS2) that mediate the estrogenic activity (Byford et al., 2002).
The possible link between the use of deodorants and the onset of breast cancer would appear, moreover, due to the fact that parabens found in the examined samples are in the ester form and not in the form of metabolites, indicating that their penetration into 'body has not taken place for oral intake (Darbre et al., 2003, 2004). Furthermore, as one of the ways used by the body to eliminate toxic products is the "perspiration", deodorants preventing, part of this phenomenon would reduce the elimination of toxins through the armpits. This would lead, over time, their accumulation at the level of the lymph glands under the arm, and then present a first step towards the formation of cancerous cells (Darbre et al., 2003).
All this is also confirmed by clinical observations, published over 10 years, showing that the majority of tumors develops at the level of the top margin outside of the breast, ie in correspondence of the area in which it is applied more deodorant (Haagensen et al., 1971).
Although the majority of studies have shown that parabens are not mutagenic (Elder et al., 1984), some have shown, however, that they can cause chromosomal alterations (Ishidate et al., 1978) and in particular it has been observed that the subcutaneous administration of metilparabeni is due to the onset of mammary adenocarcinomas in rats (Mason et al., 1971).
 It was shown, furthermore, that parabens are also able to destroy the cell function through the inhibition of the secretion of lysosomal enzymes (Bairati et al., 1994).
Other studies have also shown that most of the deodorant applied remains trapped in the axillary hairs.
This suggests, therefore, that deodorants should never be used immediately after shaving as parabens could easily enter the body through microscopic lesions originated from shaving (Darbre et al., 2003).
However, in reality the direct link between parabens and cancer is still only a hypothesis which should be confirmed by epidemiological studies in the long term and especially conducted on a larger number of samples. It should also demonstrate the presence of low concentrations of parabens in women who do not use deodorants or the presence of these compounds also in the tissues of healthy breast (Darbre et al., 2004). If, in fact, they were similar levels of parabens also in normal tissues of women who regularly use deodorants would be possible to exclude a link between the onset of cancer and the use of these products. We must, however, also emphasize the fact that find traces of them in tumor tissues would not, however, any
meaning if the levels achieved not found to be sufficient to induce biological consequences.
Were also raised doubts about the absorption process "direct" of parabens through the skin because the skin is able to metabolize, at least in part, the substances with which it comes in contact, for which reason any of their track, penetrated into the skin, it should be degraded into harmless substances by epidermal cells (Darbre et al., 2003). Some studies conducted later on animals have, however, shown that parabens can be rapidly absorbed through the skin (Whitworth et al., 1973; Fischmeister et al., 1975; Komatsu et al., 1979) due to the presence of deodorants substances that facilitate the penetration of the product into the body (Kitagawa et al., 1997) and also because in the skin and subcutaneous adipose tissue substances are present, particularly carboxylesterase, which promote the hydrolysis of parabens to p-hydroxybenzoic acid, which is more easily absorbed (Lobemeier et al., 1996; Bando et al., 1997). Moreover, they are rapidly absorbed from the gastrointestinal tract also, hydrolyzed to p-hydroxybenzoic acid, conjugated and finally rapidly excreted with urine (Jones et al., 1957; Heim et al., 1957; Tsukamoto et al., 1960, 1962, 1964; Derache et al., 1963, Philips et al., 1978; Kiwadw et al., 1979).
In addition to parabens two other compounds, present in most deodorants are liable to cause some problems for health (Alzheimer's disease, breast cancer, granulomas and CNS diseases):
aluminum and zirconium (Laden et al, 1988; Exley et al., 1998). This seems to be related to the fact that these compounds are normally present in high concentrations in products for the body hygiene, in effect:
   to .. the aluminum chlorohydrate is allowed at concentrations up to 25% (Flick et al., 1989);
   b .. aluminum chloride up to 15% (Flick et al., 1989);
   c .. hydrochloride aluminum-zirconium up to 20% (Flick et al., 1989);
In particular it has been observed that some salts, such as chloride and aluminum chlorohydrate or salts of zirconium (zirconium hydrates) are able to block the channels and inhibit sweat, and then, the normal process of transpiration (Darbre et al., 2003 ). Moreover, because of their small size these compounds are easily absorbed and may, over time, accumulate in the body, attack and damage the DNA and its ability to repair itself.
In particular, they are capable of inducing alterations in the BRCA-1 and BRCA-2 that are responsible for DNA repair, ie genes act as "tumor-suppressor" (Hilakivi-Clarke et al., 2002).
The carcinogenic action is also supported by the ability of these compounds to interfere with the processes that regulate cell growth; in particular it has been observed that aluminum is also able to modulate the topology of DNA by inducing changes in the triplet GCC-12 (Latha et al., 2002).
In 2003, another study has suggested possible mechanisms responsible for the onset of breast cancer (Darbre et al., 2003).
 In fact,  they act not only blocking the ducts of the sweat but also making it impractical ducts adjacent to the breast, thus giving rise to the formation of cysts.
Carcinogenesis of the breast may also be the result of a combination of chemical constituents present in antiperspirants (phytoestrogens, xenoestrogens, estrogen physiological or pharmacological) before that damage cells and then promote their proliferation. All this has as a consequence the occurrence of benign tumor or malignant breast. IT TAKES But also remember that in 2002 was published an epidemiological study (Mirick et al., 2002), which found no association between the use of deodorants and the occurrence of breast cancer.
It should, however, also remember that in 2002 was published an epidemiological study (Mirick et al., 2002), which found no association between the use of deodorants and the occurrence of breast cancer.
Finally, it is important to emphasize that in spite of the substances contained in deodorants meet the guidelines on safety of medicines (Laden et al., 1988), they do not show on the container directions regarding the amount to be used or the frequency of application, as is the case for products pharmaceuticals. This makes you think, mistakenly, that these products can be used in unlimited quantities and at high frequency without even remotely imagine instead that a product that is apparently so 'harmless could be harmful to your health.
It would thus be appropriate on a retrospective evaluation of long-term effects of air fresheners on the population.
Another important aspect to consider is the regulation of products containing parabens Australia, as Australia has one of the most restrictive regulatory systems in the world with regard to cosmetic products, including deodorants (Australian Government, Department of Health and Ageing ). In particular, the regulatory program in the field of cosmetics is the "National Industrial Chemicals Notification and Assessment Scheme" (NICNAS), which is a system developed in 1989 which deals with:
   a .. control the introduction on the market of chemicals (eg, dyes, solvents, plastics, etc.);
   b .. the disclosure in the workplace of hazardous chemicals;
The aim of NICNAS is, therefore, to provide all the information on these products in order to protect the industry, the public and the environment from their harmful effects. In particular, to ensure the use of effective products, but above all safe, in Australia, have been established by the Trade Practices Act of 1974, certain mandatory requirements regarding the labeling of products
cosmetics. According to this decision shall be binding on the label listing the ingredients of the product in descending order of weight or volume, in order to facilitate thus the identification by
consumers of the ingredients to which they may be allergic to or that can cause adverse reactions.
The labels must also indicate, where possible, the specific hazards caused by the various ingredients or combinations thereof.
And 'particularly mandatory shows such dangers when using the chemical component is present in the "Standard for the Uniform Scheduling of Drugs and Poisons' (SUSDP), list of substances deemed by the Australian government hazardous to health, such as parabens (Australian Government, Department of Health and Ageing).
Taken from: http://www.farmacovigilanza.org/cosmetovigilanza/corso/0406-04.asp

What does the state for "Protecting the health of the public as required by art. 32 of the Constitution? ....
for now ... NOTHING like for Vaccines, because 'it and' conditional and / or collusion with multinationals of Chemistry and vaccines, not to mention also the pollution of the foods we eat and the water we drink!

Very useful and 'also the CLAY (clay mud) eaten as a "sweet" every day or every 2 or 3 days for a period of time that generally varies from subject to subject, with a minimum of 15 days; and sometimes 'need to take it for longer periods' long. Make sure that the clay can 'bring constipation.
The mineralizing clay with his power, healing and chelator, provides a great help to all those who have to detoxify toxic substances, helping the disinfiammazione and detoxification of the digestive tract and the whole body.

Recall also that the enzyme abnormalities, the flora, the pH of the digestive and intestinal mucosa affect the health, not only in the intestine, but also at a distance anywhere in the body.

Cosmetovigilance - Deodorants and Breast Cancer
Refresher Course - By Loredana Gambardella and Lidia Sautebin, Department of Pharmacology
Experimental, Faculty of Pharmacy, University of Naples Federico II
Source: www.mednat.org